Clinical characteristics and patient symptoms associated with poor outcomes among children with COVID-19: A rapid review
https://doi.org/10.56964/pidspj20212202009
- Author:
Krista Maye D. Catibog
1
;
Ian Theodore G. Cabaluna
2
,
3
;
Anna Lisa T. Ong-Lim
1
;
Chrizarah A. San Juan
1
;
Maria Angela M. Villa
1
;
Leonila F. Dans
1
Author Information
1. Department of Pediatrics, University of the Philippines-Philippine General Hospital, Manila
2. Department of Clinical Epidemiology, University of the Philippines, Manila
3. Pacific Center for Evidence Based Healthcare, Manila
- Publication Type:Journal Article
- MeSH:
COVID-19;
Pediatrics;
Patient Acuity
- From:
Pediatric Infectious Disease Society of the Philippines Journal
2021;22(2):66-72
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To identify specific clinical characteristics and patient signs and symptoms that increase the risk of developing severe/critical COVID-19 disease or death in the pediatric population, and identify strength of these associations
Methodology:A systematic search was done in PubMed, Science Direct, Cochrane Library and grey literature databases focusing on severe and critical COVID-19 disease in the zero to eighteen year old age group until August 26, 2020. Data regarding patient characteristics, signs and symptoms on admission and disease severity were extracted. Outcomes measured were severe or critical COVID-19, Multisystem Inflammatory Syndrome in Children (MIS-C) or death. Results were pooled and meta-analyzed.
Results:Four eligible studies with a total of 292 pediatric patients with COVID-19 were examined. Older children (MD=6.62, 95%CI=4.23 to 9.00, p-value<0.00001, I2=33%) significantly present with a higher percentage of severe disease. Shortness of breath (OR=8.14, 95%CI=2.33 to 28.47, p-value=0.001, I2=42%) was also found to be associated with severe COVID-19 disease. The presence of a pre-existing medical condition (OR=4.02, 95%CI=1.55 to 10.43, p-value=0.004, I2=0%), especially cardiac disease (OR=6.40, 95%CI=1.45 to 28.38, p-value=0.01, I 2=13%) and diabetes (OR=7.01, 95%CI=1.54 to 31.95, p-value=0.01, I2=0%) was noted to be a risk factor for severe disease.
Conclusion:Based on poor quality observational studies, older age group, shortness of breath, and a pre-existing medical condition, especially cardiac disease or diabetes were found to be associated with poor outcomes in children with COVID-19.
- Full text:009_vol-22-no-2_CATIBOG_POOR-COVID-OUTCOMES.pdf
