Outcomes of HIV-Exposed infants enrolled in the Prevention of Mother to Child Transmission of HIV (PMTCT) program in Philippine General Hospital: An 8-year retrospective study
https://doi.org/10.56964/pidspj2021220107
- Author:
Anna Soleil Cheshia V. Tan
1
;
Marimel R. Pagcatipunan
1
Author Information
1. Division of Infectious and Tropical Diseases in Pediatrics Department of Pediatrics University of the Philippines - Philippine General Hospital
- Publication Type:Journal Article
- Keywords:
PMTCT;
HIV-Exposed Infant;
ARV prophylaxis
- MeSH:
HIV;
Philippines
- From:
Pediatric Infectious Disease Society of the Philippines Journal
2021;22(1):51-62
- CountryPhilippines
- Language:English
-
Abstract:
Background:Our country has the fastest growing number of HIV cases in the Asia-Pacific region with a 203% increase from 2010 to 2018. MTCT represents 6% of infections in children and interventions such as the PMTCT program are essential to help reduce new infant infections.
Objective:To determine the outcomes of HIV-exposed infants born in PGH from 2010 to 2018 enrolled in the PMTCT program. To analyze the association of maternal and neonatal clinicodemographic factors to MTCT of HIV.
Methods:A retrospective cohort study using data collected from medical records of HIV exposed infants enrolled in the program.
Results:Out of 117 mother-infant pairs, only 70 met the eligibility criteria. Maternal factors showed that majority have: timely antenatal visit (56/70), maternal HIV diagnosis (70/70) and ART initiation (67/70) prior to delivery, triple lifelong maternal ART (69/70), CD4 >200 prior to delivery (52/70) and cesarean delivery (67/70). Amongst the infant factors-early infant prophylaxis (60/62), >4weeks prophylaxis duration (62/70) and replacement feeding (62/70) were noted in the majority. 2/70 infants were HIV positive. Mortality rate was 1.4% and 50% for HIV infected infants. Overall LTFU rate was 33.3%. Logistic regression showed that maternal co-infection with Hepatitis B(p=0.0275) was a possible determinant of MTCT. Infant HIV prophylaxis duration of >4 weeks had higher survival proportion(p=.0001).
Conclusion:The HIV MTCT rate was 2.86% upon implementation of our PMTCT program, meeting the <5% goal of WHO, suggesting that the program was an effective health intervention strategy. The high LTFU rate though should be considered in the evaluation of the program effectiveness.
- Full text:07-Vol-22-No-1_Tan_Outcomes-of-HIV-Exposed-Infants-_FORMATTED_v6.pdf
