Injectable Scaffold with Microfracture using the Autologous Matrix-Induced Chondrogenesis (AMIC) Technique: A Prospective Cohort Study
https://doi.org/10.5704/MOJ.2211.014
- Author:
Bong GSY
1
;
Lee YHD
2
Author Information
1. Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore
2. Department of Orthopaedic Surgery, National University Hospital, Singapore
- Publication Type:Journal Article
- Keywords:
cartilage repair, autologous matrix-induced chondrogenesis, BST-CarGel, microfracture, outcomes
- From:Malaysian Orthopaedic Journal
2022;16(No.3):86-93
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Autologous matrix-induced chondrogenesis
(AMIC) is a one-step surgical cartilage repair procedure
involving the insertion of a scaffold into the chondral defect
after microfracture. BST-CarGel [Smith and Nephew,
Watford, England] is an injectable chitosan-based scaffold
which can more easily fill defects with irregular shapes and
be used to treat vertical or roof chondral lesions. The study
aims to evaluate the clinical outcomes of knee cartilage
repair with microfracture surgery and BST-CarGel using the
AMIC technique for a minimum of two years.
Materials and methods: A prospective study of patients
undergoing cartilage repair with microfracture surgery and
BST-CarGel at our institution from 2016 to 2019 was
performed. Clinical outcomes were determined using the
Lysholm Knee Scoring System and Knee Injury and
Osteoarthritis Outcome Score (KOOS). These questionnaires
were administered before the surgery and at a minimum of
two years after surgery.
Results: A total of 21 patients were identified and recruited
into the study. 31 cartilage defects were seen and treated in
21 knees. These included horizontal lesions (e.g., trochlear,
lateral tibial plateau), vertical lesions (e.g., medial femoral
condyle, lateral femoral condyle) and inverted lesions (e.g.,
patella). No complications or reoperations were seen in our
study population. For the average duration of follow-up of
42.5±8.55 months, there was an average improvement in
Lysholm score of 25.8±18.6 and an average improvement in
KOOS score of 22.5±15.0.
Conclusion: BST-CarGel with microfracture surgery using
the AMIC technique is a safe and effective treatment for
cartilage defects in the short to medium term.
- Full text:16.2022my1278.pdf
