Effectiveness and adverse effects of Intravenous Colistin In Neonates with Multi-Drug Resistant Gram-Negative Bacterial Infections
https://doi.org/10.56964/pidspj20202101004
- Author:
Michael N. Crisostomo
1
;
Cecilia Maramba-Lazarte
1
Author Information
1. University of the Philippines-Philippine General Hospital
- Publication Type:Journal Article
- Keywords:
MDR-GNB
- MeSH:
Colistin;
Infant, Newborn
- From:
Pediatric Infectious Disease Society of the Philippines Journal
2020;21(1):16-25
- CountryPhilippines
- Language:English
-
Abstract:
Background:The global burden of multi-drug resistant gram-negative bacterial (MDR-GNB) infections has been increasing. Neonates are at a particularly high-risk and there is limited treatment option. The use of colistin has been re-introduced for this population. However, data on its use in neonates is scarce.
Objectives:To determine the effectiveness and adverse effects of intravenous colistin in neonates with multidrug-resistant gram-negative infections.
Design:This is a retrospective cohort study of the clinical profile and outcome of neonates with MDR-GNB infections given colistin for a minimum of 3 days conducted from April 2015 to April 2019.
Results:A total of 175 pediatric patients had MDR-GNB infections. 75 (43%) neonates met the inclusion criteri a and received intravenous colistin. Of the 75 patients with MDRGNB infections- that included sepsis, pneumonia, urinary tract infection and abscess, 37 (49.3%) were alive and 38 (50.7%) patients died. Nephrotoxicity was seen in 4% if patients and 2.6% patients had hypersensitivity reaction. MDROs isolated were Acinetobacter baumanii, Klebsiella pneumoniae and Pseudomonas aeruginosa.
Conclusions:Intravenous colistin is 50% effective and is relatively safe to use in neonates.
- Full text:Vol-21-No-1_CRISOSTOMO_Intravenous-Colistin-Final.pdf
