Role of Thalamus in Analgesia of Transcutaneous Acupoint Electrical Stimulation: a Functional Magnetic Resonance Imaging Study
- VernacularTitle:丘脑在经皮穴位电刺激镇痛效果中的作用
- Author:
Lei ZHANG
;
Fang LUO
;
Huandong LI
;
Baoguo WANG
;
Xiaoyuan LIU
- Publication Type:Journal Article
- Keywords:
sufentanil, functional magnetic resonance imaging, functional connectivity, thalamus
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(11):1039-1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the analgesic mechanisms of sufentanil. Methods 17 (8 male, 9 female) healthy right-handed volunteersreceived functional magnetic resonance imaging (fMRI) scan before and after sufentanil 0.2 ng/ml administration respectively. Thalamuswas as the region of interest (ROI). All the processing works were carried out using the Statistical Parametric Mapping. Results Comparedwith the basic state, significantly weaker functional connectivity was mainly found in the region of bilateral rectal gyrus and the left inferiaorbital gyrus of the frontal lobe, while significantly greater functional connectivity was found in bilateral cerebellum, the right cingulategyrus and the left middle temporal gyrus (P<0.001, cluster>13 mm3). Conclusion Thalamus plays a key role in the central analgesia ofsufentanil, which associated with the functional connectivity of bilateral rectal gyrus and the left inferia orbital gyrus of the frontal lobe, bilateralcerebellum, the right cingulate gyrus and the left middle temporal gyrus.
