Expression of CD14 mRNA in Intestine-liver Axis Disorder during Acute Cerebral Hemorrhage and Effects of Xinglouchengqi Decoction
- VernacularTitle:CD14 mRNA的表达在急性脑出血肠-肝轴紊乱中的作用及星蒌承气汤的干预研究
- Author:
Haibin ZHAO
;
Jie TANG
;
Lihua MA
;
Wei WANG
;
Shuai WANG
;
Xiujing ZHANG
- Publication Type:Journal Article
- Keywords:
cluster of differentiation 14, acute cerebral hemorrhage, hepatic stress injury, syndrome of phledm-heat and fu-organ excess
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(11):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of CD14 on lipopolysaccharide (LPS) signal transduction pathway during the hepaticstress injury in acute cerebral hemorrhage, and explore the protection mechanism of Xinglouchengqi decoction. Methods The model ofacute cerebral hemorrhage was established with injection of collagenase Ⅶ into internal capsule of cerebrum. The rats were randomly dividedinto blank control group, cerebral hemorrhage group, syndrome of phledm-heat and fu-organ excess model group and Xinglouchengqigroup. Each group was divided into 3 time sub-groups (24 h, 48 h, 72 h). The expression of CD14 mRNA in liver tissue and mesentericlymph nodes were observed by real-time quantitative polymerase chain reaction. Results The expression of CD14 mRNA was higher in model-group than blank control group (P<0.05). Xinglouchengqi decoction could reduce liver pathological injury significantly. Conclusion CD14plays an important role in endotoxin-mediated liver injury. Xinglouchengqi decoction can protect the liver in cerebral hemorrhage.
