Effects of Rehmannia and Storesin on Nitric Oxide, Nitric Oxide Synthase and Tumor Necrosis Factor α in Early Hepatic Encephalopathy Rat Model
- VernacularTitle:地黄苏合香合剂对早期肝性脑病大鼠一氧化氮、一氧化氮合酶、肿瘤坏死因子-α的影响
- Author:
He LIU
;
Yanyong LIU
;
Nan YANG
;
Chao JI
;
Pingping ZUO
;
Tao GONG
;
Lei LIAO
;
Xiaoming HOU
;
Zhe CAI
- Publication Type:Journal Article
- Keywords:
Rehmannia, Storesin, hepatic encephalopathy, nitric oxide, nitric oxide synthase, tumor necrosis factor α, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(11):1028-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Rehmannia and Storesin (RS) on early hepatic encephalopathy (HE) in rat model.Methods HE rat model was induced by CCl4 intragastric administration. The effects of RS on serum nitric oxide (NO) and nitric oxide synthase(NOS) as well as hippocampal tumor necrosis factor α (TNF-α) level of animals were evaluated in 3 dose groups. Lactulose was usedas the positive group. Results The serum NO and NOS as well as hippocampal TNF-α level of the model rats were significantly increasedcompared with that in control animals (P<0.01). The RS high dosage treatment could significantly decrease the levels of those indexes (P<0.01). Conclusion Rehmannia and Storesin is effective on early HE by decreasing the level of serum NO and NOS as well as hippocampalTNF-α.
