Histopathological correlation between transrectal ultrasound-guided biopsy and radical prostatectomy specimen of Filipino men with localized prostate cancer: A local experience.
- Author:
Mark Oliver Christian Sebastian E. Amponin
;
Abelardo M. Prodigalidad
;
Sigrid M. Agcaoili
- Publication Type:Journal Article
- Keywords:
prostate cancer;
Gleason score;
prostatectomy;
biopsy;
transrectal ultrasonography
- From:
Philippine Journal of Urology
2019;29(1):1-5
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND:Prostate cancer is the most common malignant tumor among adult men worldwide andthe second most common cause of cancer death. Gleason grading system is a powerful predictor in theprognosis and treatment outcome of prostate carcinoma.
OBJECTIVE:This retrospective study aims to evaluate the accuracy of transrectal ultrasound (TRUS)-guided biopsy of the prostate compared to radical prostatectomy specimen in predicting thepathological grading of prostate adenocarcinoma using the Gleason scores between specimens.
METHODS:This is a review of 69 patients who underwent radical prostatectomy due to prostate cancerin 2010-2015. The Gleason scores of the transrectal ultrasound biopsies were compared with thesurgical specimen.
RESULTS:The biopsy Gleason scores obtained from the TRUS biopsy and the radical prostatectomyspecimens were similar in 79.7% of the cases. In patients with moderately differentiated tumors onbiopsy (Gleason score of 5 to 7), the concordance rate was 83% with upgrading after surgery in 16%of the cases. In poorly-differentiated tumors on biopsy (Gleason score of 8 to 10), 74% revealed thesame score on histopathological examination after radical prostatectomy, while 25% of the caseswere given lower Gleason scores after operation. Overall, 20.3% cases were discrepant by 1 or moreGleason scores after radical prostatectomy. There was a good histopathological correlation betweenTRUS biopsy and prostatectomy specimen {AUC =0.787(p=0.001)}.
CONCLUSION:The overall accuracy of Gleason score on transrectal ultrasound-guided biopsies inpredicting prostatectomy specimen grade is favorable. It plays a significant role in clinical decisionmaking of patients with prostate carcinoma.
- Full text:Histopathological correlation between transrectal ultrasound-guided biopsy.pdf
