Adrenocortical Carcinoma with Cushing’s Syndrome and Extensive Tumor Thrombosis of the Inferior Vena Cava in a 30-year-old Filipino female
https://doi.org/10.15605/jafes.037.02.10
- Author:
Kristine Abas
1
;
Maria Honolina Gomez
1
,
2
;
Jennifer Mapanao-Gonong
1
,
3
;
Rosella Arellano
4
Author Information
1. Department of Internal Medicine, Capitol Medical Center, Quezon City, Philippines
2. Section of Endocrinology, Diabetes and Metabolism, University of Santo Tomas, Faculty of Medicine and Surgery, Manila, Philippines
3. Section of Oncology, Lung Center of the Philippines, Quezon City, Philippines
4. Section of and Vascular Medicine, Philippine Heart Center, Quezon City, Philippines
- Publication Type:Case Reports
- Keywords:
Cushing’s syndrome;
Inferior vena cava thrombosis
- MeSH:
Adrenocortical Carcinoma
- From:
Journal of the ASEAN Federation of Endocrine Societies
2022;37(2):95-100
- CountryPhilippines
- Language:English
-
Abstract:
Adrenocortical carcinoma (ACC) is a rare and aggressive neoplasm with poor prognosis. We report a case of a 30-year-old female who presented with profound classic features of an adrenocorticotrophic hormone (ACTH)-independent Cushing’s syndrome (CS) and a large adrenal mass with massive venous tumor thrombosis of the entire inferior vena cava (IVC), left renal and adrenal veins confirmed by imaging. Adrenal biopsy histopathology and immunohistochemistry confirmed ACC. Systemic palliative chemotherapy was administered. This rare case presents a unique and atypical presentation of an extensive tumor thrombosis of IVC. With the advanced stage at diagnosis, aggressive nature and poor prognosis of the disease, there is still a need to determine viable therapeutic options for metastatic ACC associated with venous invasion.
- Full text:1249-Article Text-21577-1-10-20221125 (1).pdf
