Review of literature on Akkermansia muciniphila and its possible role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus
https://doi.org/10.15605/jafes.037.01.13
- Author:
Made Indira Dianti Sanjiwani
1
;
I Putu Hendri Aryadi
1
;
I Made Siswadi Semadi
2
Author Information
1. Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University, Bali, Indonesia
- Publication Type:Review
- Keywords:
Akkermansia muciniphila;
ER stress
- MeSH:
Gastrointestinal Microbiome;
Insulin Resistance;
Probiotics;
Diabetes Mellitus, Type 2
- From:
Journal of the ASEAN Federation of Endocrine Societies
2022;37(1):69-74
- CountryPhilippines
- Language:English
-
Abstract:
Akkermansia muciniphila is a promising gut microbiota for the treatment of type 2 diabetes mellitus (T2DM). A. muciniphilastimulates intestinal wall integrity, is an anti-inflammatory agent, and reduces endoplasmic reticulum stress, lipogenesis and gluconeogenesis. These properties make A. muciniphila a potential treatment option for T2DM by reducing insulin resistance and increasing insulin sensitivity and glucose tolerance in different tissues. This article explores the possible role of A. muciniphila in T2DM management, along with the various methods known to modulate A. muciniphila.
- Full text:1127-Article Text-17697-2-10-20220529.pdf
