Dermatoses in Human Immunodeficiency Virus Infected Patients with A  Focus on Infections: A 12-month Cross-sectional Study in Hospital Sungai  Buloh

Zareen Aidah Yahya; Adawiyah Jamil; Norli Marwyne Mohammed Noor

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Dermatoses in Human Immunodeficiency Virus Infected Patients with A Focus on Infections: A 12-month Cross-sectional Study in Hospital Sungai Buloh

Author: Zareen Aidah Yahya ¹ ; Adawiyah Jamil ² ; Norli Marwyne Mohammed Noor ¹
Author Information

1. Dermatology Unit, Department of Medicine, Hospital Sungai Buloh, Ministry of Health, Malaysia
2. Dermatology Unit, Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Ministry of Health, Malaysia
Publication Type:Journal Article
Keywords: HIV; Mucocutaneous manifestations; CD4 count
MeSH: HIV Infections; Dermatomycoses
From:Malaysian Journal of Dermatology 2022;48(Jun 2022):58-65
CountryMalaysia
Language:English
Abstract: Background:Cutaneous disorders are common clinical manifestations of the Human Immunodeficiency Virus (HIV). In the era of antiretroviral therapy (ART), the spectrum of cutaneous disorders in HIV-infected patients has changed. We assessed the types of dermatoses, including cutaneous infections in HIVpositive patients and the association between the peripheral CD4 cell count and the severity of skin infection.
Methods:All HIV-positive patients referred to the Dermatology Department of Hospital Sungai Buloh from January 2021 – December 2021 were enrolled in a prospective cross-sectional study. Patients were subjected to a complete medical and physical examination and appropriate investigation to confirm the diagnosis.
Results:A total of 112 (92.6%) male and 9 (7.4%) female patients with a mean age of 38.76 ± SD years participated. The majority of patients were Malay (56.2%), with MSM (54.5%) being the commonest mode of transmission. 65.2% of patients had CD4≥350 cells/ mm3 and 86.7% of patients were on ART. Infections (56.1%) were the most common group of mucocutaneous manifestations, with 45.6% of these due to viral infections. There was no statistically significant correlation between the CD4 count and the severity of skin involvement in bacterial (p=0.302), viral (p=0.145) and fungal (p=0.533) infections.
Conclusion:Viral infection were the commonest cutaneous manifestations in HIV- positive patients. The frequency and severity of the cutaneous infections were much more common in patients with more advanced immunosuppression.
Full text:15.2022my0006.pdf