The Socio-demographic and Quality of Life of People Living with HIV (PLHIV) Presenting with Cutaneous Manifestation: A Cross-Sectional Study in the Department of Dermatology, Sarawak General Hospital
- Author:
Siew Li Ee
1
;
Pubalan Muniandy
1
Author Information
- Publication Type:Journal Article
- Keywords: Human Immunodeficiency Virus; Quality of life; Cutaneous manifestation
- MeSH: HIV; Dermatomycoses--pathology
- From:Malaysian Journal of Dermatology 2022;48(Jun 2022):48-57
- CountryMalaysia
- Language:English
-
Abstract:
Background:People living with Human Immunodeficiency Virus (PLHIV) are living longer with the advent of
highly active antiviral therapy (HAART). Aside from extending the life span, quality of life is vital in
PLHIV management. However, there is a paucity of data on the cutaneous manifestations in PLHIV
on HAART. The objective of this study is to ascertain the prevalence of cutaneous manifestations,
effect on daily lives, and relation to CD4 levels.
Methods:This is a prospective cross-sectional study comparing 2 groups of PLHIV patients on HAART and not on HAART therapy done from March 2020 to November 2020.
Results:A total of 259 patients were recruited in this study with a mean age of 40 years. There were 216 (83.4%) male and 43 (16.6 %) female. Men having sex with men accounts for 49%. The most common cutaneous disorder was post-inflammatory pigmentation (20.4%). Infective dermatoses were 43 (6.7%), and cutaneous malignancy 3 (0.6%). Mean DLQI in PLHIV on HAART were 2, as compared to PLHIV not on HAART which scored 3. Bidayuh ethnicity accounts for 30% of adverse drug reactions with Bactrim being the most common drug.
Conclusion:There is a high prevalence of dermatoses in PLHIV. HAART increases the CD4 count of patients thereby reducing the risk of opportunistic infection and related disorders. However, it did not reduce the cutaneous manifestations in PLHIV, as HAART itself may increase the risk of adverse cutaneous drug reactions. DLQI is not the best tool to assess quality of life. - Full text:15.2022my0005.pdf
