Predictors of response to therapy among post Thyroidectomy adult Filipino patients with Papillary Thyroid Carcinoma based on the 2015 American Thyroid Association Guidelines
https://doi.org/10.15605/jafes.036.02.18
- Author:
Aivind Gabrielle Santiago
1
;
Maria Jocelyn Isidro
1
;
Joseph Parra
2
Author Information
1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Makati Medical Center, Makati City, Philippines
2. Oncology Unit, Makati Medical Center, Makati City, Philippines
- Publication Type:Journal Article
- Keywords:
Response to papillary thyroid cancer therapy;
Well-differentiated thyroid cancer
- MeSH:
Thyroid Cancer, Papillary
- From:
Journal of the ASEAN Federation of Endocrine Societies
2021;36(2):161-166
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To identify factors independently associated with incomplete response to therapy based on the 2015 ATA guidelines in surgically treated Filipino patients with papillary thyroid carcinoma (PTC).
Methodology:This is a retrospective cohort study of adults aged 21-74 years with papillary thyroid carcinoma (PTC) treated with surgery with or without radioactive iodine therapy (RAI) in Makati Medical Center from 2013 to 2017. We collected the following factors through a review of charts: age at diagnosis, gender, family history of thyroid cancer, date of surgery, tumor size, capsular/lymphovascular invasion, lymph node/distant metastases, stage, risk of recurrence, dose of post-surgical RAI therapy, initial post-treatment serum Thyroglobulin (Tg) and anti-Tg antibody levels (Negative Tg level: suppressed non-stimulated Tg <0.2 ng/mL or TSH-stimulated Tg <1 ng/mL; Positive Tg level: suppressed Tg ≥1 ng/mL or a TSH-stimulated Tg ≥10 ng/mL or rising anti-Tg antibody levels), thyroid stimulating hormone suppression, post-operative imaging studies and levothyroxine dose. Response to therapy was checked 6-24 months post-therapy.
Results:We analyzed a total of 115 patients with PTC who underwent thyroidectomy. Patients who had family history of thyroid cancer were less likely to have an incomplete or indeterminate response (p=0.045). None of the patients with excellent response had lymphovascular invasion. Having a positive Tg (p=0.001) and positive anti-Tg postoperatively (p<0.001) were strongly associated with incomplete or indeterminate response.
Conclusion:Patients who were positive for thyroglobulin and anti-thyroglobulin post-operatively were strongly associated with incomplete or indeterminate response to therapy in PTC.
- Full text:1095-Article Text-14953-2-10-20211125 (1).pdf
