Cryptorchidism is a useful clue for Idiopathic Hypogonadotropic Hypogonadism in Pituitary Stalk Thickening
- Author:
Shamharini Nagaratnam
1
;
Subashini Rajoo
1
;
Mohamed Badrulnizam Long Bidin
1
;
Norzaini Rose Mohd Zain
2
Author Information
- Publication Type:Case Reports
- Keywords: Hypogonadotrophic hypogonadism
- MeSH: Pituitary Diseases; Hypopituitarism; Cryptorchidism; Growth Hormone
- From: Journal of the ASEAN Federation of Endocrine Societies 2021;36(1):95-97
- CountryPhilippines
- Language:English
- Abstract: Pituitary stalk lesions can represent a wide range of pathologies. The exact cause is often unknown due to hesitancy to proceed with biopsy. We present a 16-year-old adolescent who presented with delayed puberty, short stature and bilateral cryptorchidism. He was found to have a thickened pituitary stalk of uncertain etiology with partial hypopituitarism (gonadotrophin and growth hormone deficiency) on further assessment. The presence of bilateral cryptorchidism and micropenis represents lack of “mini puberty,” a phenomenon of activation of the hypothalamic-pituitary-gonadal (HPG) axis in-utero or within the first few months of life.1 These key clinical features have been useful to establish an early temporal relationship and suggest a congenital origin of disease. This enabled a more conservative approach of surveillance to be employed as opposed to invasive pathological examination with pituitary stalk biopsy.
- Full text:1007-Article Text-13245-2-10-20210530.pdf
