Survival of Filipino children with acute lymphoblastic leukemia diagnosed in a tertiary referral center for childhood cancer: A retrospective cohort study.
- Author:
Trixy G. Chu
;
Arden Mae S. Shiu
;
Ma. Beatriz P. Gepte
;
Ma. Cecilia Leongson-Cruz
- Publication Type:Journal Article
- Keywords:
Childhood Acute Lymphoblastic Leukemia;
Filipino;
Overall survival;
Event Free Survival
- From:
The Philippine Children’s Medical Center Journal
2019;15(2):20-34
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND:Acute lymphoblastic leukemia (ALL) represents the largest group of pediatric
malignancies. The high cure rate of childhood ALL represents one of the most remarkable success stories
in the war against cancer. In a lower middle income country (LMIC) like the Philippines, we reviewed the
5-year survival in a tertiary referral center.
OBJECTIVES:This study aims to determine the 5-year survival of childhood ALL at a tertiary referral
center for childhood cancer.
METHODOLOGY:Medical charts of newly diagnosed ALL ages 1 to 18 years old from January 2012
to December 2016 were reviewed.
OUTCOME:A total of 435 subjects were included in the study. The 5-year overall survival (OS) and
event free survival (EFS) were 65.3% and 62.8%, respectively. The 5-year OS for standard risk ALL was
68.8% and for high risk ALL was 50%. The 5-year OS for the remission group was 83.7% and for the
relapse was 21.1%. Univariate and multivariate analysis showed that WBC count at diagnosis, risk
classification, immunophenotyping, and relapse showed significant prognostic impact for mortality.
CONCLUSION:The 5-year OS and EFS were lower compared to developed countries but are
comparable with other LMICs. The prognostic factors for relapse and mortality were compatible with the
literature. Overall, the adopted treatment protocols for childhood ALL in this institution showed
acceptable results.
- Full text:Survival of Filipino children with.pdf
