Correlation study between Erythrocyte Acetylcholinesterase activity, Serum Malondialdehyde and Insulin sensitivity in Agricultural workers and non-agricultural workers in Nat-Kan Village, Magway Township
https://doi.org/10.15605/jafes.035.01.14
- Author:
Mya Pwint Phyu
1
;
Zarchi Theint Theint Hlain
1
;
Thurein Zaw
1
;
Soe Minn Htway
1
;
Mya Thanda Sein
1
Author Information
1. Department of Physiology, University of Medicine, Magway, Magway Regional Division, The Republic Union of Myanmar
- Publication Type:Journal Article
- Keywords:
Erythrocyte acetylcholinesterase activity;
Serum malondialdehyde level;
HOMA-IR
- MeSH:
Farmers
- From:
Journal of the ASEAN Federation of Endocrine Societies
2020;35(1):85-92
- CountryPhilippines
- Language:English
-
Abstract:
Objective:This study determined the correlation between erythrocyte acetylcholinesterase (AChE) activity, serum malondialdehyde (MDA) and insulin sensitivity in agricultural workers and non-agricultural workers.
Methodology:The cross-sectional comparative study was undertaken in 45 agricultural and 45 non-agricultural workers from Nat-Kan Village, Magway Township. Erythrocyte acetylcholinesterase activity and serum malondialdehyde were measured by spectrophotometric method. Insulin sensitivity was calculated by homeostasis model assessment (HOMA-IR).
Results:Mean erythrocyte AChE activity was significantly lower in agricultural (3553.99 IU/L) compared with non-agricultural workers (4432.68 IU/L) (p<0.001). A significant high level of mean serum MDA was observed in agricultural workers (0.74 versus 0.28 μmol/L, p<0.001). Median HOMA-IR value was significantly higher in agricultural (2.74) than that of non-agricultural workers (2.28) (p<0.05). The risk of insulin resistance was 2.8 times greater in agricultural workers than non-agricultural workers (OR 2.8, 95% CI, 1.18 to 6.72). Erythrocyte AChE activity had weak negative correlation with serum MDA level (r=-0.357, p<0.001) and HOMA-IR (ρ= -0.305, p<0.05). There was a significant but weak positive correlation between serum MDA level and HOMA-IR (ρ=0.355, p<0.001).
Conclusion:Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Oxidative stress is partly attributed to the development of insulin resistance
- Full text:645-Article Text-10031-1-10-20200529.pdf
