Accuracy of transcutaneous bilirubin determination in neonatal hyperbilirubinemia: A meta-analysis.
- Author:
Jean Kamil L. Sy
;
Michael M. Resurreccion
- Publication Type:Journal Article
- Keywords:
Transcutaneous bilirubin;
Term and late preterm;
serum bilirubin;
hyperbilirubinemia
- From:
The Philippine Children’s Medical Center Journal
2019;15(1):66-76
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND:Timely initiation of therapy for neonatal hyperbilirubinemia is routinely made based
on total serum bilirubin levels. However, serial samplings by invasive needle pricks are needed for
laboratory analyses. Studies comparing the correlation between serum bilirubin and transcutaneous
bilirubin have yielded diverse results. A meta- analysis was done to find out the relationship between
transcutaneous bilirubin measurements and serum bilirubin values.
OBJECTIVE:This study aims to analyze scientific articles regarding the accuracy of transcutaneous
bilirubin measurements among healthy neonates as an alternative screening for hyperbilirubinemia.
STUDY DESIGN:Diagnostic Accuracy meta- analysis.
METHODS:Studies on the accuracy of transcutaneous bilirubin measurements were identified through
intensive literature search. Local studies were confirmed thru personal communication.
RESULTS:Three hundred eighteen studies were identified through literature search. Ten studies met the
eligibility criteria. Eight of the ten studies reported results as correlation coefficients. The pooled
estimates of correlation coefficients is high at r = 0.85 (95% CI = 0.84 to 0.857). Five studies reported
results with data for diagnostic accuracy. The pooled analysis for sensitivity and specificity are high at
0.84 (95% CI 0.8-0.88) and 0.79 (95% CI 0.77-0.81) respectively. The pooled likelihood ratio has a
significant difference with a pooled positive LR of 4.19 (95% CI 2.98-5.9, P<0.01) while the negative
likelihood ratio is 0.23 (95% CI: 0.17 to 0.29). The AUC for transcutaneous bilirubinometry is 0.89.
CONCLUSIONS:Transcutaneous bilirubin measurement can be an alternative in monitoring the risk of
healthy neonates for hyperbilirubinemia based on the pooled analysis of correlation coefficient and
diagnostic accuracy.
- Full text:Accuracy of transcutaneous bilirubin determination.pdf
