A Case of Overwhelming Postsplenectomy Infection following Allogeneic Hematopoietic Stem Cell Transplantation: Visualization of Diplococcus in Peripheral Blood Smear.
- Author:
Yang Soo KIM
1
;
Ji Hyeon JU
;
Ho Yun CHUNG
;
Ji Sung CHUN
;
Su Mi CHOI
;
Dong Gun LEE
;
Jung Hyun CHOI
;
Chang Ki MIN
;
Dong Wook KIM
;
Wan Shik SHIN
;
Chun Choo KIM
Author Information
1. Department of Internal Medicine, College of Medicine The Catholic University of Korea, Seoul, Korea. symonlee@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Splenectomy;
Hematopoietic stem cell transplantation;
Streptococcus pneumoniae
- MeSH:
Adult;
Cyclosporine;
Diagnosis;
Diarrhea;
Emergency Service, Hospital;
Female;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Renal Insufficiency;
Splenectomy;
Streptococcus pneumoniae
- From:Korean Journal of Infectious Diseases
2000;32(6):448-451
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fulminant, potentially life threatening infection is a major long term risk after splenectomy. This syndrome is called overwhelming postsplenectomy infection (OPSI). OPSI has a rapidly deteriorating course that progresses to respiratory and renal failure, cardiovascular collapse, and death finally. A 40-year-old woman with chronic myelogenous leukemia was admitted through the emergency room due to abdominal discomfort and diarrhea. Three years ago she had undergone splenectomy, and had received allogeneic hematopoietic stem cell transplantation 22 months before. She suffered from chronic graft-versus-host disease and was treated with prolonged corticosteroid and cyclosporine. A diagnosis of OPSI due to Streptococcus pneumoniae was made based on peripheral blood smear and blood culture findings. Despite the early aggressive care and antibiotic treatment, her clinical course was rapidly deteriorated and died 10 hours later.
