Subcutaneous Panniculitis-like T-cell lymphoma.
- Author:
Alexander B. Suplico, Jr.
;
Maria Beatriz P. Gepte
- Publication Type:Journal Article
- From:
The Philippine Children’s Medical Center Journal
2021;17(2):60-73
- CountryPhilippines
- Language:English
-
Abstract:
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cytotoxic T-cell
lymphoma of the skin localized primarily in the subcutaneous adipose tissue. Clinically, the skin
lesions mimic lipomas, but histologically resemble panniculitis, which is an inflammation of the
subcutaneous fats. Most cases have an excellent prognosis and follow an indolent clinical course
with a 5-year overall survival rate of 80%. So far, only a few cases have been reported in the
pediatric age group. The diagnosis of SPTCL is based on the combination of clinical
presentation, histopathologic examination of the skin lesion, immunohistochemical staining, and
molecular analysis. Notably, data on treatment of pediatric SPTCL are even fewer in number,
and very few patients undergoing effective treatment have been documented.
This is a case report of a 15-year-old female adolescent diagnosed with Subcutaneous
panniculitis-like T-cell lymphoma who presented with multiple, non-tender, erythematous to
violaceous deep dermal and subcutaneous nodules on the lower extremities associated with
myalgia, intermittent moderate-grade fever, and weight loss over the past 7 months. She was
initially managed as a case of ―growing pain‖ and acute rheumatic fever, until histopathologic
findings of the nodules showed inflammation of the subcutaneous fats, and
immunohistochemistry revealed findings consistent with SPTCL. She is currently being treated
with multi-agent combination chemotherapy which resulted in improvement of symptoms.
- Full text:Subcutaneous Panniculitis-like T-cell lymphoma.pdf
