Effect of Elevated Basal LH on IVF-ET Outcomes in Patients with Polycystic Ovary Syndrome
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20221113.001
- VernacularTitle:多囊卵巢综合征患者基础LH升高对IVF-ET结局影响
- Author:
Wei-e ZHAO
1
;
Xiao-ping LIU
1
;
Pan-yu CHEN
1
;
Xiao-yan LIANG
1
;
Jing-jie LI
1
Author Information
1. Reproductive Medicine Research Center， The Sixth Affiliated Hospital of Sun Yat-sen University // Guangdong Engineering Technology Research Center of Fertility Preservation， Guangzhou 510000， China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
luteinizing hormone;
gonadotropin-releasing hormone antagonist
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(1):78-84
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the outcomes in controlled ovarian stimulation （COH） and fresh embryo transfer between women with and those without a high basal luteinizing hormone （bLH） level in polycystic ovary syndrome （PCOS）. MethodsThe clinical data of PCOS patients at the Reproductive Medicine Center of the Sixth Hospital of Sun Yat-sen University from January 2015 to December 2021 were retrospectively analyzed. They were divided into the high group （LH≥10 U/L） and normal group （LH<10 U/L） according to the bLH levels. The results of COH and pregnancy outcomes after fresh transfer were compared， including gonadotropin （Gn） initiation dose， Gn duration， total Gn dose， number of oocytes obtained， two pronuclei （2PN） rate， available embryos rate， high-quality embryos rate， blastocyst formation rate， human chorionic gonadotrophin （HCG） positive rate， clinical pregnancy rate （CPR）， spontaneous abortion rate （SAR）， ongoing pregnancy rate （OPR） and live birth rate （LBR）. The differences in hormonal trends during COH were also analyzed. ResultsThere were no statistically significant differences in age， body mass index， anti-Mullerian hormone， and type of infertility between the two groups. Compared with the normal group， the Gn initiation dose and Gn duration were not statistically significant （P>0.05）， while the total Gn dose was significantly lower （P<0.001） in the high group. The number of oocytes retrieved， 2PN rate， available embryos rate， high-quality embryos rate， and blastocyst formation rate were comparable between the two groups （all P>0.05）. After fresh embryo transfer， they had similar pregnancy outcomes in the HCG positive rate， CPR， SAR， OPR and LBR （all P > 0.05）. ConclusionsIn patients with PCOS， high bLH levels do not affect COH or pregnancy outcomes in fresh transfer cycles. Further studies are needed to determine whether LH levels need to be lowered prior to COH and whether frozen-all strategy is required in patients with elevated bLH levels.
