Safety and efficacy of buccal midazolam compared to rectal diazepam for the acute treatment of seizures in children: A meta-analysis.
- Author:
Maria Isabel B. Calingo
;
Marjorie Grace M. Apigo
;
Mel Michel G. Villaluz
- Publication Type:Journal Article
- Keywords:
buccal midazolam;
rectal diazepam;
seizures
- From:
The Philippine Children’s Medical Center Journal
2021;17(2):1-9
- CountryPhilippines
- Language:English
-
Abstract:
OBJECTIVE:To compare the safety and efficacy of buccal midazolam as opposed to rectal
diazepam in the treatment of acute seizures in children less than 18 years old.
METHODOLOGY:This is a meta-analysis of randomized controlled trials comparing the use
of buccal midazolam and rectal diazepam as treatment for acute seizures in children less than 18
years old. The total population of each study are as follows: 330 patients (Mpimbaza, 2008), 43
patients (Baysun, 2005), and 17 patients, all less than 18 years old, coming into the emergency
department due to seizures.
RESULTS:There is no significant difference in the mean duration of seizure in minutes and
seizure cessation in ten minutes between the buccal midazolam and rectal diazepam groups
(Mean difference 0.39; 95% Confidence interval [CI] -0.18 to 0.96; p=0.17; Risk ratio [RR]
0.99; 95% CI 0.83 to 1,19, p=0.2). There is no significant difference in the risk of respiratory
depression between buccal midazolam and rectal diazepam (RR 0.96; 95% CI 0.22 to 4.13;
p=0.61).
CONCLUSION:The administration of buccal midazolam and rectal diazepam are similar in
terms of efficacy and safety in terms of time to seizure cessation, termination of seizure within
ten minutes, and risk of respiratory depression.
- Full text:Safety and efficacy of buccal midazolam.pdf
