Cytokine-Mediated Regulatory Networks Between Skeletal Muscle System and Immune System
10.16156/j.1004-7220.2022.02.29
- VernacularTitle:细胞因子介导的骨骼肌系统与免疫系统间调控网络
- Author:
Zihan ZHANG
1
,
2
,
3
;
Huan YANG
4
;
Qingsheng HUANG
4
;
Hui YANG
1
,
2
,
3
Author Information
1. School of Life Sciences
2. Biomechanics & Medical Engineering Research Center of Special Environment
3. Northwestern Polytechnical University
4. School of Life Sciences,Northwestern Polytechnical University
- Publication Type:Journal Article
- Keywords:
skeletal muscle;
immune;
cytokines;
mechanical stimulation
- From:
Journal of Medical Biomechanics
2022;37(2):E374-E378
- CountryChina
- Language:Chinese
-
Abstract:
There is a tight regulatory network between the skeletal muscle system and the immune system, and they are jointly involved in functional regulation and response of the skeletal muscle system and the immune system. Cytokines are important signaling molecules that constitute this regulatory network. The cytokines produced by skeletal muscle atrophy and the cytokines produced by mechanical stimulation of skeletal muscle have different compositions and biological effects. The normal immune system and abnormal immune function can also affect skeletal muscle through the synergistic effect of different cytokines. According to this, a complex regulatory network between the two major systems is formed. The cytokine-mediated regulatory network between the skeletal muscle system and the immune system was reviewed in order to provide the theoretical basis for prevention and treatment of the skeletal muscle atrophy and mechanical intervention of the body immune function.
