Numerical Analysis on Degradation of Cartilage Scaffold under Perfusion Loading
10.16156/j.1004-7220.2022.02.04
- VernacularTitle:灌流载荷作用下软骨支架降解仿真研究
- Author:
Ying WEI
1
;
Yansong TAN
1
;
Lilan GAO
1
,
2
;
Ruixin LI
3
;
Chunqiu ZHANG
1
Author Information
1. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology
2. Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid
3. Central Laboratory, Tianjin Stomatological Hospital
- Publication Type:Journal Article
- Keywords:
perfusion;
tissue engineering;
numerical simulation;
degradation;
fluid-solid interaction
- From:
Journal of Medical Biomechanics
2022;37(2):E219-E224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of irrigation mechanical stimulation on scaffold degradation by numerical simulation, so as to predict its degradation degree. MethodsBased on perfusion experimental data, the fluid-solid coupling model was established by Comsol. The finite element model of scaffold was established by ABAQUS. Based on the models, the degradation performance of scaffold was simulated and predicted. Results The fluid-solid coupling simulation showed that the initial pressure at the speed of 15.79 mL/min was two-fold of that at 7.89 mL/min. Along the thickness of scaffold from the surface to the bottom, the pressures between the two velocities were decreased and gradually close to each other. The degradation of scaffold structure could be simulated dynamically by combining the degradation constitutive model with the finite element model. The obtained degradation data were consistent with the experimental data, and the residual molecular weight reached 0.643 on the 56th day. Compared with the experimental data, the simulation accuracy was higher than 98%. Conclusions The larger the perfusion velocity is, the greater the pressure on scaffold will be. Under the same perfusion velocity, the maximum force occurs on the surface of scaffold. The degradation pattern of scaffold can be predicted by applying the degradation constitutive model and the finite element model.
