Biomechanical Environment Regulates Biomimetic Mineralization of Bone Matrix
10.16156/j.1004-7220.2022.02.02
- VernacularTitle:力学环境调控骨基质仿生矿化
- Author:
Chunyang MA
1
,
2
,
3
,
4
;
Tianming DU
5
;
Xufeng NIU
1
,
2
,
3
,
4
;
Yubo FAN
1
,
2
,
3
,
4
Author Information
1. Beijing Advanced Innovation Center for Biomedical Engineering
2. Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education
3. Beijing Key Laboratory for Optimal Design, Test & Evaluation Technology of High-End Medical Implants and Interventional Instruments
4. Institute for Medicine and Engineering Interdisciplinary Innovation, School of Biological Science and Medical Engineering, School of Medical Science and Engineering, Beihang University
5. Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Department of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology
- Publication Type:Journal Article
- Keywords:
bone matrix;
biomimetic mineralization;
collagen;
fluid shear stress (FSS);
bone repair materials
- From:
Journal of Medical Biomechanics
2022;37(2):E200-E210
- CountryChina
- Language:Chinese
-
Abstract:
Bone defects have always been an important cause of threat to human health, and artificial biomimetic bone repair replacement materials are currently one of the most effective and feasible solution approaches to treat bone damage. To develop artificial bone biomimetic materials, an in vitro biomimetic mineralization system must be constructed first to study in vitro biomimetic mineralization mechanism of natural bone matrix. Collagen is a template for mineralization, and its properties such as crosslinking degree, diameter, osmotic pressure, and surface charge can all directly affect mineralization progress. The biochemical and mechanical environments in which mineralization occurs are also quite distinct in their effects on mineralization process, particularly noncollagenous proteins and fluid shear stress (FSS). FSS is considered to be the main mechanical stimulation of bone tissues in micro-environment, which is of great significance to bone growth, repair and health maintenance. FSS at different levels and loading regimes has significant effects on transformation of amorphous calcium phosphate to bone apatite, self-assembly and directional alignment of collagen fibrils, and formation of hierarchical intrafibrillar mineralization. In this paper, the factors affecting collagen mineralization and their mechanism were summarized, with focus on regulation of FSS on collagen mineralization, and development direction in future was also prospected.
