Role of Oxidative Stress in Osteoporosis and Treatment by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.2022002026
- VernacularTitle:中医药调控氧化应激治疗骨质疏松症的研究进展
- Author:
Jian YUAN
1
;
Lingjun KONG
2
;
Jun ZHAO
2
;
Yuquan WANG
2
;
Zhaohui LIU
2
;
Xingguo LI
2
;
Delong YANG
2
;
Chenliang WANG
1
Author Information
1. Clinical College of Chinese Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Gansu Provincial Hospital of Traditional Chinese Medicine， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
oxidative stress;
osteoblast
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(6):268-274
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a systemic metabolic bone disease. Amid population aging， OP has become a major health problem for the middle-aged and the elderly in China. Aging， iron load， and estrogen deficiency break the balance between oxidation and antioxidant systems， and the increase of reactive oxygen species mediates oxidative stress to damage DNA， lipids， proteins and other macromolecules， thus accelerating cell apoptosis and inducing OP， obesity， and neurodegenerative disorders. It has been found that oxidative stress is of great significance in the pathogenesis of OP. Oxidative stress regulates the signaling pathways， cytokines， and proteins related to the mesenchymal stem cells， osteoblasts， and osteoclasts， thereby weakening the osteogenic differentiation of mesenchymal stem cells， inhibiting osteoblast mineralization， and promoting the activation， proliferation， and maturation of osteoclasts. As a result， the dynamic imbalance between bone resorption and bone formation occurs， influencing bone remodeling and promoting the progression of OP. At the moment， anti-bone resorption drugs， bone formation-promoting drugs， and hormones are mainly used in clinical settings in western medicine. However， due to the long treatment cycle and the occurrence of serious gastrointestinal reactions， hypocalcemia， osteonecrosis， and others， patients show poor compliance and thus the effect is not as expected. Traditional Chinese medicine （TCM） demonstrates remarkable effect on OP attributing to the multi-pathway and multi-target characteristics. With low price and few adverse reactions， TCM is widely applied in clinical practice in comparison with western medicine. TCM has unique advantages in the treatment of OP by regulating oxidative stress. It exerts the therapeutic effect on OP by modulating different signaling pathways， providing new mindset for the treatment of this disease. Therefore， through literature research， this study summarized the research on mechanism of oxidative stress in OP and the treatment by TCM， which is expected to lay a foundation for further research.
