White Matter Damage in Major Depressive Disorder and TCM Treatment： A Review
10.13422/j.cnki.syfjx.20221901
- VernacularTitle:重度抑郁症中的白质损伤及中医药治疗现状
- Author:
Li LIU
1
;
Qingwu LIU
2
;
Xue FENG
1
;
Tao LI
1
;
Bin LIU
1
;
Yaqing LIU
1
;
Xinke DU
1
;
Qi LI
1
;
Weipeng YANG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. China-Japan Friendship Hospital，Beijing 100029，China
- Publication Type:Review
- Keywords:
major depressive disorder;
white matter damage;
white matter repair;
microglia
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(6):237-245
- CountryChina
- Language:Chinese
-
Abstract:
At present， major depressive disorder （MDD） is highly prevalent with advanced neurological disorders as the main pathological manifestations. As the physiological function bearer of higher neural activity， gray matter has become the focus of MDD treatment. However， recent research has shown that white matter and gray matter are independent of each other in the central nervous system （CNS）， and their functions are integrated and linked. In addition to gray matter damage， white matter damage is also the core driving event of disease progression and determines the outcome of MDD. At the treatment level， the current drug treatment of MDD mainly focuses on gray matter repair， while ignoring the importance of white matter integrity for the treatment of the disease， which has become the weakness of the current treatment of MDD. Traditional Chinese medicine （TCM） has good application potential in white matter repair. This paper elaborated on the following three aspects. ① The roles of white matter damage in the occurrence and development of MDD were summarized. ② The key link of white matter repair in MDD was elaborated with microglia microenvironment regulation as the entry point. ③ The application value of TCM in white matter repair in MDD was analyzed. This review aims to highlight the importance of white matter integrity in the treatment of MDD and is expected to expand the understanding dimension of the activity of related Chinese medicines in MDD from the perspective of white matter repair and analyze its potential application value.
