Parathyroid Carcinoma: Analysis of patient characteristics and outcomes in a retrospective review of eight cases seen in a single center
- Author:
Shamira Shahar
1
;
Kim Piow Lim
1
;
Masni Mohamad
1
Author Information
- Publication Type:Case Reports
- MeSH: Parathyroid Neoplasms; Carcinoma; Hypercalcemia
- From: Journal of the ASEAN Federation of Endocrine Societies 2019;34(2):229-232
- CountryPhilippines
- Language:English
- Abstract: Eight cases of parathyroid carcinoma were identified (8 females; median age 45 years, range 28-72). Half of whom were diagnosed preoperatively. Hypercalcemic symptoms were seen in 87.5% of the patients and the main complication was nephrolithiasis. At presentation, the median calcium was 3.675 mmol/L, median phosphate of 0.68 mmol/L, median intact parathyroid hormone (iPTH) was 211 pmol/L. Five patients had regional nodes metastasis and 1 had distant metastasis to the lungs. Parathyroid gland invasion to adjacent structures was seen in 62.5% of cases while another 62.5% showed capsular or vascular infiltration on histology with median tumour size of 3.2 cm. Recurrent hypercalcemia occurred in 50% of the patients with median time of recurrence of 21 months. In this case series, we found that patients with severe hypercalcemia and high iPTH also exhibited a high index suspicion of PC.
- Full text:675-Article Text-8571-1-10-20191112.pdf
