A systematic review and meta-analysis on effectiveness of rice-based oral rehydrating solution for the treatment of acute watery diarrhea among children.
- Author:
Mercellaine Marie S. Mangahas
;
Michael M. Resurreccion
- Publication Type:Journal Article
- Keywords:
children;
pediatric;
oral rehydrating solution;
glucose-based ORS;
rice-based ORS
- From:
The Philippine Children’s Medical Center Journal
2021;17(1):25-35
- CountryPhilippines
- Language:English
-
Abstract:
OBJECTIVES:This study aims to compare the effectiveness of rice-based ORS as compared
with glucose-based ORS in the treatment of acute watery diarrhea among children. Specifically,
it aims to review and analyze the effectiveness of rice-based ORS as compared to glucose-based
ORS as to stool output, duration of diarrhea and effect of osmolarity on treatment of diarrhea and
to determine associated adverse events associated with rice-based ORS and glucose-based ORS.
METHOD:This study used systemic review and meta-analysis of randomized trials. Primary
outcomes were computed with 95% confidence intervals to determine the effectiveness of ricebased ORS. Adverse event was expressed as risk ratios with 95% confidence intervals.
RESULTS:Sixteen studies met the criteria for the systematic review and meta-analysis.
Duration of acute diarrhea was shorter by 5 hours with rice-based ORS (MD= −5.27 hours, 95%
CI= −9.63 to −0.91, p-value= 0.02) compared to glucose-based ORS. The stool output was 62.35
mL/kg lower with rice-based ORS (MD= −62.35 mL/kg, 95%CI= −128.43 to 3.74, p-value=
0.06) compared to glucose-based ORS. Vomiting was the only reported associated event with
ORS intake (RR= 1.08, 95%CI= 0.81to 1.43, p-value= 0.60).
CONCLUSION: Sixteen studies met the criteria for the systematic review and meta-analysis.
Duration of acute diarrhea was shorter by 5 hours with rice-based ORS (MD= −5.27 hours, 95%
CI= −9.63 to −0.91, p-value= 0.02) compared to glucose-based ORS. The stool output was 62.35
mL/kg lower with rice-based ORS (MD= −62.35 mL/kg, 95%CI= −128.43 to 3.74, p-value=
0.06) compared to glucose-based ORS. Vomiting was the only reported associated event with
ORS intake (RR= 1.08, 95%CI= 0.81to 1.43, p-value= 0.60).
- Full text:A systematic review and meta-analysis..pdf
