Effectiveness of immature Mangifera indica Linn (mango) fruit in reducing the Ascaris lumbricoides infection among children: a non-inferiority randomized controlled trial.
- Author:
Arianna Julia S. Enriquez
;
Grachella Jana Beatriz M. Erlano
;
John Ruben A. Esperanza
;
Michael Kevin H. Espino
;
Jan Paola B. Frayna
;
Anne Christine E. Gagui
;
Gerald M. Gaitos
;
Raquelynne M. Galicia
;
Joseph R. Gallardo
;
James Rainier M. Garcia
;
Ma. Cristina Z. Garcia
;
Jose Ronilo G. Juangco
1
Author Information
1. Department of Preventive and Community Medicine, College of Medicine, Univer-sity of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, PH
- Publication Type:Journal Article
- Keywords:
soil transmitted helminthiasis;
helminth;
mango
- MeSH:
Ascariasis
- From:
Health Sciences Journal
2018;7(2):73-79
- CountryPhilippines
- Language:English
-
Abstract:
INTRODUCTION:This study aimed to compare the effectiveness of immature Magnifera indica L. (mango) fruit with albendazole in reducing Ascaris lumbricoides infection among children.
METHODS:Children aged 2 to 14 years were enrolled in a randomized, controlled, non-inferiority trial. Participants were randomly allocated to receive 250 mL immature mango fruit puree daily for 3 days or one dose of albendazole 400 mg tablet. Egg reduction rates and cure rates were computed and compared. Adverse effects were monitored during and after administration of treatment.
RESULTS:There was a statistically significant decrease between the pre- and post-treatment EPG of those who took immature mango fruit (p < 0.001) and those who took albendazole (p < 0.001). There was a higher ERR and CR for the albendazole group, but the difference was not significant (p = 0.472, p = 785, respectively). Risk analysis of reduction in intensity showed mango is non-inferior to albendazole (RR = 0.80, 95% CI 0.67, 0.97; p = 0.026). Risk analysis of cure showed mango is noninferior to albendazole in both PP (RR = 0.92, 95% CI 0.68, 1.25; p = 0.607) and ITT (RR=0.79, 95% CI 0.58, 1.08; p = 0.139).
CONCLUSION:Immature Mangifera indica Linn is non-inferior to albendazole in terms of effectiveness in the reduction of ascariasis infection.
- Full text:Effectiveness of immature Mangifera indica Linn.pdf
