Hypoglycaemia among insulin-treated patients with Diabetes: Southeast Asia Cohort of IO HAT Study
https://doi.org/10.15605/jafes.033.01.05
- Author:
Faruque Pathan
1
;
Su-Yen Goh
2
;
Achmad Rudijanto
3
;
Arvind Gadekar
4
;
Anand Jain
5
;
Nemencio Nicodemus Jr.
6
Author Information
1. Department of Endocrinology, BIRDEM Hospital, Dhaka, Bangladesh
2. Singapore General Hospital, Singapore
3. Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Malang, Indonesia
4. Novo Nordisk Pharma Operations (BAOS) Sdn. Bhd, Kuala Lumpur, Malaysia
5. Novo Nordisk Health Care AG, Zurich, Switzerland
6. College of Medicine, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
Hypoglycaemia;
Diabetes
- MeSH:
Insulin
- From:
Journal of the ASEAN Federation of Endocrine Societies
2018;33(1):28-36
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To provide real-world data on hypoglycaemia incidence in patients with type 1 (T1D) or type 2 diabetes (T2D) from the Southeast Asian cohort of the International Operations Hypoglycaemia Assessment Tool (IO HAT) study.
Methodology:IO HAT was a non-interventional, multicentre, 6-month retrospective and 4-week prospective study of hypoglycaemic events among insulin-treated adults with T1D or T2D, including four countries in Southeast Asia (Singapore, Philippines, Indonesia, and Bangladesh). Data were collected using a two-part self-assessment questionnaire (SAQ1 for retrospective and SAQ2 for prospective). The primary endpoint was the percentage of patients experiencing at least one hypoglycaemic event during the 4-week prospective observational period (ClinicalTrials.gov Identifier: NCT02306681).
Results:A total of 2594 patients completed SAQ1. Nearly all patients reported experiencing any hypoglycaemic event in the 4-week prospective period (T1D, 100%; T2D, 97.3%), with all patients reporting higher rates in the prospective versus retrospective period. Severe hypoglycaemia was also reported higher prospectively (57.2% and 76.9%) than retrospectively (33.9% and 12.2%) in both T1D and T2D, respectively. Nocturnal hypoglycaemia was reported higher retrospectively than prospectively.
Conclusion:Incidence of any and severe hypoglycaemia in the Southeast Asian cohort of IO HAT was higher prospectively versus retrospectively, suggesting hypoglycaemia has previously been under-reported in this region.
- Full text:434-Article.pdf
