Association of 5-59A/G Polymorphism in Intron Region of Htra2 Gene with Parkinson's Disease
- VernacularTitle:Htra2基因内含子5-59A/G位点多态性与帕金森病的相关性研究
- Author:
Xiyao ZHAO
;
Yusen CHEN
;
Fangmei HE
;
Lei ZHAO
;
Liangfang LIU
;
Jiangang PAN
;
Bin ZHAO
- Publication Type:Journal Article
- Keywords:
Htra2 gene, single-nucleotide polymorphism, Parkinson's disease
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(7):650-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between the single-nucleotide polymorphism (SNP) of the 5-59A/G (rs2241027) of Htra2 gene and Parkinson's disease in Han population of the western GuangDong province. MethodsThe restriction fragment length polymorphism (PCR-RFLP) was used to determine the 5-59A/G polymorphism in the intron region of Htra2 gene in the case group (n=56) and healthy control group (n=109). ResultsA allele frequency of 5-59 A/G in cases (46.4%) was trended to more than that in controls (36.7%) (P=0.073), as well as the AA genotyping frequency (21.4% vs 11.0%, P=0.072). For the male, the frequency of AA genotype was significantly more in cases (25.7%) than that in controls (10.3%） (P=0.041), and the frequency of A allele was trended to more in cases (48.6%) than in controls (34.6%) (P=0.051). ConclusionA allele and AA genotype of the 5-59A/G (rs2241027) of Htra2 gene may increase the risk of suffering from Parkinson's disease, especially for males.
