Cerebral salt-wasting syndrome after hematopoietic stem cell transplantation in adolescents: 3 case reports.
10.6065/apem.2015.20.4.220
- Author:
Yeon Jin JEON
1
;
Hyun Young LEE
;
In Ah JUNG
;
Won Kyoung CHO
;
Bin CHO
;
Byung Kyu SUH
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. suhbk@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Hyponatremia;
Sodium;
Polyuria;
Hematopoietic stem cell transplantation
- MeSH:
Central Nervous System;
Cerebral Hemorrhage;
Dehydration;
Diagnosis;
Encephalitis;
Fludrocortisone;
Hematopoietic Stem Cell Transplantation*;
Hematopoietic Stem Cells*;
Humans;
Hyponatremia;
Leukemia;
Natriuresis;
Polyuria;
Rare Diseases;
Sodium;
Water
- From:Annals of Pediatric Endocrinology & Metabolism
2015;20(4):220-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cerebral salt-wasting syndrome (CSWS) is a rare disease characterized by a extracellular volume depletion and hyponatremia induced by marked natriuresis. It is mainly reported in patients who experience a central nervous system insult, such as cerebral hemorrhage or encephalitis. The syndrome of inappropriate antidiuretic hormone secretion is a main cause of severe hyponatremia after hematopoietic stem cell transplantation, whereas CSWS is rarely reported. We report 3 patients with childhood acute leukemia who developed CSWS with central nervous system complication after hematopoietic stem cell transplantation. The diagnosis of CSW was made on the basis of severe hyponatremia accompanied by increased urine output with clinical signs of dehydration. All patients showed elevated natriuretic peptide and normal antidiuretic hormone. Aggressive water and sodium replacement treatment was instituted in all 3 patients and 2 of them were effectively recovered, the other one was required to add fludrocortisone administration.
