Research progress on the pathogenicity of Porphyromonas gingivalis clinical strains
10.12016/j.issn.2096-1456.2023.05.009
- Author:
WU Yajie
1
,
2
,
3
;
LI Yuqing
1
,
2
,
4
;
ZHOU Fangjie
1
,
2
,
3
;
LI Jiyao
1
,
2
,
3
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases &
3. Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
4. West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
periodontitis / Porphyromonas gingivalis / clinical strains / standard strains / fimbriae / capsule / lipopolysaccharide / gingipains
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(5):365-369
- CountryChina
- Language:Chinese
-
Abstract:
Porphyromonas gingivalis (P. gingivalis) is closely related to the occurrence and development of periodontitis. It is considered to be one of the important pathogens leading to alveolar bone resorption. At present, research on P. gingivalis mostly adopts standard laboratory strains whose genetic characteristics have been confirmed, are guaranteed and are traceable, such as ATCC 33277. The virulence phenotypes (endotoxin, firmbria, etc.) of clinically extracted isolates are quite different from those of standard strains, and the pathogenic effects and ability of the host are also widely different. In addition, P. gingivalis is considered to have a significant correlation with a variety of systemic diseases, and the virulence characteristics and pathogenic ability of different strains will have different effects on systemic diseases. However, at present, there is a lack of research on clinical strains and standard strains, and there is a lack of systematic comparison between the two sources of bacteria. In this paper, the differences in the virulence phenotypes and pathogenic effects between clinical isolates and standard strains of P. gingivalis in the last 5-10 years are reviewed. The aim is to elucidate the important virulence gene loci in the P. gingivalis gene sequence, which will play an important role in improving therapeutic methods and the development of related drugs.
- Full text:牙龈卟啉单胞菌临床菌株致病作用的研究进展.pdf
