Effect of Stilbene on Lowering Blood Glucose of Rats with Type 2 Diabetes
- VernacularTitle:二苯乙烯对2 型糖尿病大鼠降血糖作用的实验研究
- Author:
Qingping YANG
;
Farong YU
;
Hongxia CHE
;
Mei ZHANG
;
Ruiping HU
;
Qinhu WANG
;
Lei SHI
- Publication Type:Journal Article
- Keywords:
stilbene, type 2 diabetes, blood glucose, lipid
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(8):745-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of stilbene on blood glucose of rats with type 2 diabetes. Methods 50 male Wistar rats wererandomly divided into model group (n=40) and control group (n=10). The model group was given fat emulsion 40 days continuously with 20ml/kg, po, and streptozotocin with 120 mg/kg on the 41st day, 100 mg/kg on the 42nd day, i.p. After the modeling, the model group was dividedinto 4 groups with 10 in each. They were given stilbene with 500 ml/kg, 200 ml/kg, 100 ml/kg and metformin with 100 mg/kg, ip, respectively.The level of blood glucose, blood lipid and glycogen content were determined. Results After the modeling, the blood glucoseand TG, TC, LDL-C, HDL-C increased by 140.89%, 25.77%, 275.52%, 105.54% and 31.25% respectively (P<0.01); after stilbene was given,the level of blood glucose and lipid decreased significantly (P<0.05), the liver glycogen content increased significantly by 8.06%~16.17% compared to the control group. Conclusion Stilbene can decrease the concentration of blood glucose and lipid, and increase the liverglycogen content of rats with type 2 diabetes.
