Research progress on oxidative stress regulatory mechanisms in Streptococcus mutans
10.12016/j.issn.2096-1456.2023.04.012
- Author:
NING Jia
1
,
2
;
HU Xin
1
,
2
;
CHENG Xingqun
3
,
4
Author Information
1. Department of General Dentistry, School &
2. Hospital of Stomatology, Tianjin Medical University
3. Department of Geriatric Dentistry, the State Key Laboratory of Oral Diseases &
4. National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
Streptococcus mutans / oxidative stress / hydrogen peroxide / oral microecology / dental caries / dental plaque biofilm / cariogenic mechanism
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(4):295-300
- CountryChina
- Language:Chinese
-
Abstract:
The oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is closely related to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include the synthesis of reductase, the regulation of iron and manganese uptake by metalloregulatory proteins, transcription regulator Spx, extracellular uptake of glutathione and other related signal transduction systems. The current research focuses on how S. mutans adapts to a complex external environment through an oxidative stress response and its influence on oral microecology. We can design targeted small molecular compounds for key signaling pathways to inhibit oxidative stress and weaken the virulence of S. mutans, which is important for oral microecological modulation and dental caries prevention and treatment.
- Full text:变异链球菌氧化应激调控机制的研究进展.pdf
