Systematic review of clinical effects of enamel matrix derivative as adjunctive therapy for gingival recession
10.12016/j.issn.2096-1456.2023.04.006
- Author:
XU Ruonan
1
;
WEI Yiru
1
;
YANG Xintong
2
;
GULINUER Awuti
1
Author Information
1. 1.Periodontal and Mucosal Department, the First Affiliated Hospital of Xinjiang Medical University (the Affiliated Stomatology Hospital of Xinjiang Medical University) 2.Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region
2. Periodontal and Mucosal Department, the First Affiliated Hospital of Xinjiang Medical University (the Affiliated Stomatology Hospital of Xinjiang Medical University)
- Publication Type:Journal Article
- Keywords:
enamel matrix derivative / connective tissue graft / gingival recession / keratinized tissue width / probing depth / clinical attachment loss / randomized controlled trial / meta analysis / systematic review
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(4):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To evaluate the clinical effect of enamel matrix derivative(EMD) assisted with connective tissue graft(CTG) in the treatment of gingival recession.
Methods :Search The Cochrane Library, PubMed, EMbase, Web of Science, Wanfang Public Database,VIP database and CNKI to search for randomized controlled trials of EMD in the treatment of gingival recession. The search period is from the establishment of the databases to October 3, 2022. The test group was treated with EMD+CTG, while the control group was treated with CTG alone. Meta-analyses were performed using Review Manager 5.4.1 and Stat12.0.
Results: Meta analysis results showed that only 12 months after treatment, there was a statistically significant difference in the PD and CAL outcome indicators between the EMD assisted treatment group and the control group [MDPD=-0.10, 95% CI (-0.19, -0.01), P = 0.03], [MDCAL=-0.38, 95% CI(-0.71, -0.04), P = 0.03]. There was no significant difference between the test group and the control group in other indicators.
Conclusion :EMD assisted CTG in the treatment of gingival recession may be beneficial to the reduction of PD and CAL.
- Full text:釉基质蛋白衍生物辅助治疗牙龈退缩临床效果的系统评价.pdf
