Paraparesis in a young adult: A case report on Neurofibromatosis-2
- Author:
Tristan M. Colasito
1
;
Bayani Pocholo T. Maglinte
1
;
Jeremyjones F. Robles
2
,
3
Author Information
- Publication Type:Case Reports
- MeSH: Neurofibromatoses; Neurilemmoma; Neurofibroma; Paraparesis; Bevacizumab
- From: Philippine Journal of Internal Medicine 2022;60(4):313-316
- CountryPhilippines
- Language:English
-
Abstract:
Background:Neurofibromatosis-2 (NF2) is a rare neurocutaneous syndrome that typically presents with hearing loss,
tinnitus, or weakness associated with few subcutaneous nodules. In contrast to neurofibromatosis-1 (NF1), NF2 presents clinically with more central lesions rather than peripheral lesions. The presence of bilateral vestibular schwannomas through imaging studies distinguishes NF2 from other neurocutaneous syndromes.
Case:This is a case of an 18-year-old male who presented with lower paraparesis with associated hearing loss, cataract, and a few subcutaneous nodules. Centrally located lesions were suspected, thus brain and spine magnetic resonance imaging (MRI) were done revealing bilateral vestibular schwannomas and spine neurofibromas. The patient and family were advised for tumor surveillance, and apprised of surgical intervention once with brainstem compression symptoms.
Conclusion:NF2 is a rare debilitating disease that may lead to multiple neurologic deficits. The absence of recommended medical treatment and the multifocality of the tumors leave surgical resection a high-risk treatment option. Early recognition by tumor surveillance may give patients with NF2 a better prognosis and survivability. - Full text:13 - Paraparesis.pdf
