The Effects of TGF-beta2 and bFGF on the Proliferation of Retinal Pigment Epithelial Cells.
- Author:
Hee Seong YOON
1
;
Sae Heun ROH
;
Sung Chul LEE
;
Jin Hee JEONG
;
Young Hyun YOO
Author Information
1. .
- Publication Type:Original Article
- Keywords:
bFGF;
PLC-yl;
retinal pigment epithelial cell;
TGF-beta2;
tyro sine kinase
- MeSH:
Epithelial Cells*;
Fibroblast Growth Factor 2;
Genistein;
Intercellular Signaling Peptides and Proteins;
Oligonucleotides, Antisense;
Protein-Tyrosine Kinases;
Retinaldehyde*;
Transforming Growth Factor beta2*
- From:Journal of the Korean Ophthalmological Society
1998;39(6):1192-1203
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was undertaken to document the effect of transforming growth factor-beta2 (TGF-beta2(TGF-beta2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas bFGF increased the proliferation, TGF-beta2 showed the inhibitory effect on the proliferation The inhibitory effect of TGF-beta2 disappeared in RPE subcultured with 10ng/ml of bFGF. Both TGF-beta2- and bFGF-specific antisense oligonucleotides blocked the autocrine effect of the growth factors. PLC-71 -specific antisense oligonucleotide inhibited the effect of TGF-beta2 and bFGF. Genistein inhibited the effect of TGF-beta2 and bFGF in dose-dependent man, ner. The data suggest the involvement. of in PLC-/1 and tyrosine kinase in signalling.
