In vivo confocal microscopic observations of 49 patients with posterior polymorphous corneal dystrophy
10.3980/j.issn.1672-5123.2023.2.24
- VernacularTitle:后部多形性角膜营养不良49例共聚焦显微镜影像学观察
- Author:
Cui-Juan XIE
1
;
Ying-Jie GUO
1
;
Xin YU
1
;
Yang ZHANG
1
;
Tian-Mei ZHAO
1
;
Jie HOU
1
Author Information
1. Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
posterior polymorphous corneal dystrophy;
in vivo confocal microscopy;
Descemet membrane;
endothelium
- From:
International Eye Science
2023;23(2):305-311
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the imaging features of 49 patients with posterior polymorphous corneal dystrophy(PPCD)by in vivo confocal microscopy(IVCM).METHODS: Retrospective case series study. A total of 49 patients(86 eyes), including 32 males and 17 females diagnosed with PPCD between January 2013 and January 2021 were collected. The mean age was 42.5±22.9 years. All patients were scanned by IVCM to analyze the density of corneal endothelial cells and described IVCM characteristics of different types of PPCD.RESULTS: The number of endothelial cells in the lesion area of all patients was lower than that in the peripheral area. Under IVCM, 44 eyes(51%)were categorized into type 1 PPCD(vesicular lesions), characterized by single or multiple, central round or irregular crater-like lesion on paracentral corneal endothelial layer; 16 eyes(19%)were categorized into type 2 PPCD(band lesions), which displayed curved and raised edge with scattered or banded-distributed gutta-like lesion between edges. Type 3 PPCD(diffuse lesion)were in 26 eyes(30%), which showed that endothelial cells were missing in many areas. The blurred images of endothelium in most areas featured with spikes lined in a streak, and the clear images in some areas featured with a band lesions. Two patients were followed up for 4-5a. The IVCM images showed different lesions, including the decrease of central corneal endothelial cell density and the iron deposit in the corneal epithelium, etc.CONCLUSION: IVCM is able to scan the characteristic microstructural alterations at the level of endothelium and Descemet membrane in patients with PPCD, and provide an effective image diagnosis for PPCD.
