Traditinal Chinese Medicine Intervention in Intervertebral Disc Degeneration by Regulating Matrix Metalloproteinase Expression： A Review
10.13422/j.cnki.syfjx.20230595
- VernacularTitle:中医药干预基质金属蛋白酶表达治疗椎间盘退变研究进展
- Author:
Jirong ZHAO
1
;
Zhenghan YANG
1
;
Junfei MA
1
;
Qianwen CHEN
1
;
Tianlong ZHANG
2
;
Peng JIANG
1
;
Ning ZHAO
2
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Gansu Provincial Hospital of Chinese Medicine，Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
matrix metalloproteinase;
intervertebral disc degeneration;
extracellular matrix
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(5):272-282
- CountryChina
- Language:Chinese
-
Abstract:
Intervertebral disc degeneration is one of the common causes of chronic low back pain. As a common spinal disease， its clinical symptoms are mainly low back pain and limited function， which seriously affects physical and psychological health. Because of its complex and unclear pathogenesis， the treatment of intervertebral disc degeneration has been the focus of scientific researchers and clinical workers. At present， the treatment of intervertebral disc degeneration mainly includes non-surgical therapy and surgical therapy， which can alleviate the clinical symptoms of patients to a certain extent， but easily induce new complications， and it is difficult to restore the normal physiological function of the intervertebral disc. In recent years， along with the advanced research on matrix metalloproteinases （MMPs） in the tissues of intervertebral disc degeneration， it has been found that MMPs can be used as molecular therapeutic targets. The expression of MMPs in the intervertebral disc tissues can be regulated by reducing the content and composition of the extracellular matrix of the intervertebral disc， so as to slow down intervertebral disc degeneration and even reverse the occurrence of intervertebral disc degeneration. This treatment is expected to delay intervertebral disc degeneration caused by changes in extracellular matrix composition or content. In recent years， with the continuous development of network pharmacology and bioinformatics research， a large number of researchers have explored the treatment of intervertebral disc degeneration by traditional Chinese medicine （TCM） and found that TCM can reduce the degradation of extracellular matrix by inhibiting the expression of MMPs， thus alleviating the symptoms of intervertebral disc degeneration and slowing down the progression of intervertebral disc degeneration. This paper reviewed the research progress of TCM intervention in MMP expression in the treatment of intervertebral disc degeneration， aiming at providing references for the application of TCM in the prevention and treatment of intervertebral disc degeneration.
