Association Between Ferroptosis and Central Nervous System Diseases and A Review of Traditional Chinese Medicine Intervention
10.13422/j.cnki.syfjx.20221904
- VernacularTitle:铁死亡与中枢神经系统疾病的关联概述及中医药干预进展
- Author:
Hao LIU
1
;
Hanying XU
1
;
Zhong SHI
2
;
Fan YAO
2
;
Ziyue TIAN
1
;
Tianye LAN
2
;
Weimin ZHAO
2
Author Information
1. Changchun University of Chinese Medicine，Changchun 130117，China
2. The Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China
- Publication Type:Journal Article
- Keywords:
ferroptosis;
traditional Chinese medicine;
central nervous system;
acupuncture and moxibustion
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(5):246-256
- CountryChina
- Language:Chinese
-
Abstract:
Central nervous system （CNS） is a sophisticated system subject to complex regulation， which dominates the high-level neural activities of the human body. Due to its complex physiological structure and refined regulatory mechanism covering a variety of diseases， CNS is the place where many chronic， refractory and rare diseases occur. Nerve cell is the basic unit of CNS， and its dysfunction and death is the root cause of CNS diseases. Ferroptosis is a new form of programmed cell death proposed in recent years， and has been proved to be closely related to the production and development of multiple CNS diseases. Traditional Chinese medicine （TCM）， including Chinese herbs， acupuncture and moxibustion， and massage， has shown unique advantages in the treatment of CNS diseases for a long time. A large number of studies have demonstrated that TCM participates in the regulation of CNS diseases via regulating ferroptosis and shows a good research prospect. This paper summarized the characteristics of ferroptosis and discussed the association between ferroptosis and CNS diseases in pathological mechanism. We also reviewed the regulation of various CNS diseases by different TCM interventions through ferroptosis， providing references for TCM to participate in the treatment of CNS diseases properly in the future.
