Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis
10.3969/j.issn.1001-5256.2023.01.011
- VernacularTitle:再代偿乙型肝炎肝硬化患者发生慢加急性肝衰竭的临床特点及预后分析
- Author:
Lei LIU
1
,
2
,
3
,
4
,
5
;
Jing LIANG
1
,
2
,
3
,
4
,
5
;
Baiguo XU
1
,
2
,
3
,
4
,
5
;
Fei WANG
1
,
2
,
3
,
4
,
5
;
Jia LIAN
1
,
2
,
3
,
4
,
5
;
Yankai YANG
2
,
3
,
4
,
5
Author Information
1. The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China
2. Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital
3. Tianjin Key Laboratory of Artificial Cells
4. Tianjin Institute of Hepatobiliary Disease
5. Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China
- Publication Type:Original Article_Viral Hepatitis
- Keywords:
Hepatitis B;
Liver Cirrhosis;
Acute-On-Chronic Liver Failure;
Prognosis
- From:
Journal of Clinical Hepatology
2023;39(1):70-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical characteristics of acute-on-chronic liver failure in patients with recompensatory hepatitis B cirrhosis. Methods A total of 180 patients with acute-on-chronic liver failure hospitalized in Tianjin Third Central Hospital from September 2013 to September 2021 were retrospectively collected, with 110 patients had compensatory hepatitis B cirrhosis and 70 patients had compensatory hepatitis B cirrhosis and used as the control. Their causes, clinical biochemical indicators, complication rate, and prognosis were compared. The Chi-square test or Fisher's exact test was used for comparison of categorical variables between groups, and the Mann-Whitney U test was performed for analysis of the continuous variables. Kaplan-Meier curves and Log-rank test were used for survival of patients. Results The incidence of hepatorenal syndrome ( χ 2 =4.618, P =0.032), infection ( χ 2 =6.712, P =0.010), Cr ( Z =-4.508, P < 0.001), and PCT ( Z =-2.052, P =0.040) were all higher, whereas GGT ( Z =-2.042, P =0.041), Na ( Z =-2.001, P =0.045), FBS ( Z =-3.065, P =0.002), and TC ( Z =-4.268, P < 0.001) were all lower in the recompensation group than in the control group of patients. However, 90-day mortality rate ( χ 2 =3.366, P =0.067) and 1-year mortality rate ( χ 2 =1.893, P =0.169), 90-day survival ( χ 2 =2.68, P =0.100), and 1-year survival ( χ 2 =2.074, P =0.150) were not statistically significant difference. Conclusion Compared with compensatory hepatitis B cirrhosis, patients with recompensatory cirrhosis had an increased risk in developing hepatorenal syndrome, infection, and increased creatinine level after acute-on-chronic liver failure, although there was no statistically significant difference in 90-days and 1-year survival of patients.
