Research advances in the impact of phthalates on cholestatic liver disease
10.3969/j.issn.1001-5256.2023.01.035
- VernacularTitle:邻苯二甲酸酯对胆汁淤积性肝病影响的研究进展
- Author:
Jiayi ZHANG
1
,
2
;
Jianqing WANG
1
,
2
Author Information
1. Department of Pharmacy, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230012, China
2. School of Pharmacy, Anhui Medical University, Hefei 230022, China
- Publication Type:Review
- Keywords:
Cholestasis;
Cholic Acid;
Phthalic Acid Esters
- From:
Journal of Clinical Hepatology
2023;39(1):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver disease is a common hepatobiliary disease caused by bile deposition in the liver due to the disorders of bile production, excretion, and metabolism. At present, the pathogenic factors for cholestatic liver disease have not been fully elucidated, but some researchers believe that environmental factors may play an important role in it. As environmental pollutants, phthalic acid esters (PAE) have been confirmed to interfere with human endocrine system, exert a potential toxic effect on the human body, endanger liver and kidney function, and increase the risk of intrahepatic cholestasis. On this basis, this article reviews the association between PAE and cholestatic liver disease and summarizes related clinical studies, animal experimental studies, in vitro experimental studies, and potential mechanisms, so as to provide ideas and references for the prevention and clinical treatment of cholestatic liver disease.
