Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway
10.3969/j.issn.1001-5256.2023.01.034
- VernacularTitle:基于PD-1/PD-L1信号通路的肝棘球蚴病免疫逃逸研究
- Author:
Kangjie YANG
1
;
Yongliang LU
2
;
Weijian E
2
Author Information
1. School of Medicine, Qinghai University, Xining 810000, China
2. Department of Clinical Laboratory, The Affiliated Hospital of Qinghai University, Xining 810000, China
- Publication Type:Review
- Keywords:
Echinococcosis, Hepatic;
Programmed Death 1;
PD-1 Ligand;
Tumor Escape
- From:
Journal of Clinical Hepatology
2023;39(1):218-225
- CountryChina
- Language:Chinese
-
Abstract:
PD-1 and PD-L1 together constitute the stimulus signaling pathway of adaptive immune response, which has been widely used in the research on the mechanism of tumor immune escape and tumor therapy. At the same time, its signaling pathway has been proved to be closely associated with the immune escape of hepatic echinococcosis. This article reviews the chemical structures of PD-1 and PD-L1, the mechanism of the PD-1/PD-L1 signaling pathway, and the role of the PD-1/PD-L1 signaling pathway in immune escape of hepatic echinococcosis, i.e., the PD-1/PD-L1 signaling pathway is involved in immune escape of hepatic echinococcosis under three theories, so as to explore the immune escape of hepatic echinococcosis from a new perspective and provide a basis and ideas for the diagnosis and treatment of hepatic echinococcosis.
