Application and potential value of endogenous lipid mediators in liver failure
10.3969/j.issn.1001-5256.2023.01.033
- VernacularTitle:内源性脂质介质在肝衰竭中的应用及潜在价值
- Author:
Gengjie YAN
1
;
Yong LIN
1
;
Huiji SU
1
;
Hanxiao CHEN
1
;
Shaoqun BAN
1
;
Ailing WEI
1
,
2
;
Dewen MAO
2
;
Fuli LONG
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2. Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Review
- Keywords:
Liver Failure, Acute;
Inflammation;
Immunity
- From:
Journal of Clinical Hepatology
2023;39(1):211-217
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a common end-stage liver disease syndrome in clinical practice characterized by massive necrosis of hepatocytes leading to rapid liver failure, and it is currently believed that excessive inflammation and immune response are the core mechanisms of this disease. Endogenous lipid mediators are involved in the regulation of a variety of inflammatory processes, including initiation, maintenance, and regression, and eicosanoids and pro-decomposition lipid mediators, as well as their complex metabolic pathways and transduction signals, play a key role in the regulation of these processes. This article reviews the key role of endogenous lipid mediators in the pathophysiological mechanism of inflammation and immune dysfunction in liver failure and the potential significance and new therapeutic opportunities of lipid immune pathway in liver failure, in order to provide new ideas for the clinical diagnosis and treatment of liver failure.
