Research advances in the reversal of liver fibrosis
10.3969/j.issn.1001-5256.2023.01.030
- VernacularTitle:肝纤维化逆转的研究进展
- Author:
Manbiao LI
1
;
Jinyu LI
2
;
Duiping FENG
2
Author Information
1. School of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China
2. Department of Oncology and Vascular Intervention, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Liver Cirrhosis;
Hepatic Stellate Cells;
Histology;
Serology
- From:
Journal of Clinical Hepatology
2023;39(1):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Chronic liver injury caused by any etiology will lead to liver fibrosis, and it was believed in the past that liver fibrosis is a static and irreversible pathophysiological process. In recent years, with the rapid development of molecular biology and the in-depth research on the microscopic aspect of the liver, more and more evidence has shown that liver fibrosis is a dynamic and reversible process. This article reviews the reports of different methods for evaluating the reversal of liver fibrosis caused by various etiologies, summarizes the pathogenesis and reversal mechanism of liver fibrosis, reviews the therapeutic drugs for reversal, and summarizes the current evaluation methods for liver fibrosis, and finally, it is believed that timely clearance or control of potential etiology may help to achieve the reversal of liver fibrosis to a certain degree.
