Role of pyroptosis in nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2023.01.027
- VernacularTitle:细胞焦亡在非酒精性脂肪性肝病中的作用
- Author:
Jingya YIN
1
;
Bingqing YANG
1
;
Yue LI
2
Author Information
1. Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
2. Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Publication Type:Review
- Keywords:
Non-alcoholic Fatty Liver Disease;
Pyroptosis;
Inflammasomes
- From:
Journal of Clinical Hepatology
2023;39(1):175-180
- CountryChina
- Language:Chinese
-
Abstract:
As a novel mode of cell death, pyroptosis plays an important role in nonalcoholic fatty liver disease (NAFLD), and the research on pyroptosis may help to explore new therapeutic targets for NAFLD. This article reviews the advances in pyroptosis from the research background and mechanism of pyroptosis and the role of pyroptosis in NAFLD and elaborates on the pyroptosis execution molecules such as GSDME and caspase-11 and the function of inflammasomes including AIM2.
