Cardiac Function in Patients with Myocardial Infarction Treated with Spironolactone: A Doppler Tissue Imaging Study
- VernacularTitle:心肌梗死患者抗醛固酮治疗后心功能变化的多普勒组织成像研究
- Author:
Changfu LIU
;
Xiaokun HUO
;
Tingshu YANG
;
Guang ZHI
;
Yong XU
;
Baoshi HAN
- Publication Type:Journal Article
- Keywords:
myocardial infarction, aldosterone antagonists, Doppler tissue imaging, cardiac function
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(5):413-414
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effects of anti-aldosterone on left ventricular function in patients with myocardial infarction. Methods130 patients with myocardial infarction were divided into anti-aldosterone group (spironolactone 20～40 mg/d + enalapril 10～20 mg/day, n=61) and control group (enalapril 10～20 mg/d, n=69). The echocardiogram and Doppler tissue imaging (DTI) were performed at enrolling time, and 6, 12 months after treatment. ResultsIn the anti-aldosterone group, the average mitral systolic wave (s) was significantly increased 6 months after treatment （P<0.05） to the enrolling time. LVEF and LVEDD improved 12 months after treatment （P<0.05）. In the control group, the average mitral systolic wave, LVEDD and LVEF did not significantly improve (P>0.05). Ratio of peak early to late diastolic filling velocity (e/a) was no significantly different between the anti-aldosterone group and the control group. ConclusionThe combination of anti-aldosterone and ACEI in patients with myocardial infarction can improve the left ventricular systolic function after 6 and 12 months, but cannot to the diastolic function.
