Correlation between High-sensitivity C Reactive Protein and Oxygen Uptake Efficiency Slope in Patients with Cardiovascular Disease
- VernacularTitle:心血管疾病患者血清超敏C-反应蛋白与摄氧效率斜率的相关性研究
- Author:
Shoulin LI
;
Shen MENG
;
Jie LIU
;
Wei LIN
;
Yan ZHANG
;
Jing ZHANG
;
Yajing LIN
;
Siyuan CHEN
;
Guodong WANG
;
Shengjie LUO
;
Zufu YANG
- Publication Type:Journal Article
- Keywords:
coronary artery disease, essential hypertension, stable angina pectoris, high-sensitivity C reactive protein, oxygen uptake efficiency slope, exercise tests
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(5):408-410
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship between high-sensitivity C reactive protein （hs-CRP） and oxygen uptake efficiency slope (OUES) in patents with cardiovascular disease. MethodsExercise tests, following a symptom-limited standard Bruce protocol with simultaneous respiratory gas-exchange measurements, were performed on a treadmill in 17 post-PCI patients, 21 stable angina pectoris and 24 patients with essential hypertension (EH). The oxygen uptake (VO2), minute ventilation (VE) were determined. The OUES was derived from the relation between VO2 (ml/min) and VE (L/min) during incremental exercise and was determined by VO2=a×lgVE+b, where a = OUES. The OUES was calculated from data of the first 75% (OUES75) and 100% (OUES100) of exercise duration. The serum hs-CRP was measured by immunoassays, and the left ventricular ejection fraction (LVEF) was measured with echocardiography. ResultsOUES75 （r=-0.506,P＜0.001）, OUES100 （r=-0.567,P＜0.001） and LVEF （r=-0.286,P＜0.01） were correlated with lg(hs-CRP). In stepwise multivariable linear regression models, lg(hs-CRP) （β=-0.374，P=0.006）, body height （β=-1.854，P=0.036）, body weight （β=-5.033，P=0.034）were independent risk factors of lower OUES75. lg(hs-CRP) （β=-0.396，P=0.003）, body height （β=-2.157，P=0.013）, body weight （β=-5.912，P=0.011） were independent risk factors of lower OUES100. ConclusionThe serum leveles of hs-CRP may be the useful marker that reflecting cardiopulmonary functional reserve and left ventricular function.
