Advances in dose-effect and biomarker studies of uranium-induced kidney injury
- VernacularTitle:铀致肾脏损伤剂量-效应关系及生物标志物研究进展
- Author:
Lianfeng ZHAO
1
;
Xiaona GU
1
;
Jingming ZHAN
1
;
Xiangming XUE
1
;
Lixia SU
1
;
Xue YANG
1
Author Information
- Publication Type:Review
- Keywords: uranium; kidney; dose-effect relationship; damage threshold; biomarker
- From: Journal of Environmental and Occupational Medicine 2022;39(9):1069-1075
- CountryChina
- Language:Chinese
- Abstract: With the development of nuclear energy technology and the use of depleted uranium weapons, the uranium exposed population is gradually expanding and the health effects of uranium exposure are of increasing concern. The toxicity of uranium to kidney, a sensitive organ for uranium to enter the body to produce effects, cannot be ignored. As of now, the effects of uranium exposure on the kidney are still not well understood, the threshold of uranium-induced kidney injury has been controversial, and there is a lack of sensitive and specific biomarkers for the diagnosis of early kindey damage, especially in the context of chronic uranium exposure. For these reasons, this paper reviewed the results of research on dose-effect relationships and biomarkers of uranium-induced kidney injury and provided an outlook on future research directions, with the aim of providing a basis for subsequent study on animal experiments and population health effects related to uranium exposure.
